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  • Bridge_National_DTI protocol_Updated_May2026
    This is the recommended starting protocol for most EDs and new programs This algorithm initiates weekly long-acting injectable buprenorphine (XR bup) without a sublingual (SL) lead-in for patients with opioid use disorder (OUD)
  • San Francisco Department of Public Health S OPE
    • WAIT to take supplemental sublingual buprenorphine for 24 hours after injection to minimize risk of precipitating withdrawal • Patient can safely receive monthly Brixadi or Sublocade starting 24 hours after a weekly Brixadi injection of 16mg or greater
  • ScalaNW_LAI_Buprenorphine-Protocol_V7
    This protocol suggests using the Brixadi® weekly dose to initiate treatment due to lower risk of opioid withdrawal Other LAI buprenorphine formulations are also appropriate Engage in shared decision making with the patient prior to initiating treatment
  • Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low . . .
    These findings suggest that this protocol is a promising potential pathway for patients to start buprenorphine in the outpatient setting
  • Treatment Protocol Package - June 2026
    Guidance on the importance of continuing buprenorphine or methadone and starting additional medications to treat acute pain Methadone may be a better choice for some people This Quick Start is for people not already on methadone for OUD Guidance on buprenorphine initiation for pregnant patients
  • Injectable Buprenorphine: Getting Started - adai. uw. edu
    For both Sublocade and Brixadi, supplemental SL-BUP may be needed in the early weeks of induction for break-through symptoms
  • GETTING STARTED ON BUPRENORPHINE: Direct-to-Inject (DTI) Initiation Method
    The Direct-to-Inject (DTI) method for opioid use disorder starts treatment using Brixadi, a long-acting buprenorphine injection, instead of the usual buprenorphine strips or tablets
  • BRIXADI (buprenorphine ) etended-release injection for subcutaneous use . . .
    This guide contains information on the appropriate use of BRIXADI® (buprenorphine) extended-release injection for subcutaneous use, which is a single-dose, sterile pre-filled syringe for the treatment of moderate-to-severe opioid use disorder
  • DTI (NAHEWD)
    Know where to go for resources implementation support •Experienced as withdrawal •Antagonist effect Day1: Dissolve 1 4 tab under tongue morning,noon,evening,bedtime Day2: 1 2 tab morning,noon,evening,bedtime Day3: 1 tab morning,noon,evening,bedtime • DTI: Initiation of bup via 2nd-gen weekly LAI w o prior SL test dose
  • BRIXADI Dosing Guide
    BRIXADI is the ONLY injectable buprenorphine that offers multiple monthly and weekly dosing options Patients currently on transmucosal buprenorphine treatment can be switched directly to BrixADI Monthly or BrixADI Weekly





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