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  • U. S. FDA Grants Full Approval to Pfizer’s BRAFTOVI Combination Regimen . . .
    BRAFTOVI ® (encorafenib) is indicated, in combination with cetuximab and fluorouracil-based chemotherapy, for the treatment of adult patients with metastatic colorectal cancer (mCRC) with a BRAF V600E mutation, as detected by an FDA-authorized test
  • ESMO 2026 Guideline: Redefining the Management of Metastatic Colorectal . . .
    Metastatic colorectal cancer (mCRC) represents a complex and biologically diverse disease in which treatment decisions increasingly depend on molecular characteristics, disease burden, and patient-specific factors
  • Treatment of Metastatic Colorectal Cancer: ASCO Guideline
    PURPOSETo develop recommendations for treatment of patients with metastatic colorectal cancer (mCRC) METHODSASCO convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice RESULTSFive
  • Metastatic colorectal cancer: ESMO Clinical Practice Guideline for . . .
    Figure 1 Management of mCRC potentially amenable to locoregional therapy Purple: algorithm title; blue: systemic anticancer therapy or their combination; turquoise: non-systemic anticancer therapies or combination of treatment modalities; white: other aspects of management and non-treatment aspects CEA, carcinoembryonic antigen; ChT, chemotherapy; CRLM, colorectal liver metastasis; dMMR, MMR
  • Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer
    First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E–mutated metastatic colorectal cancer
  • Colon Cancer, Version 3. 2024, NCCN Clinical Practice Guidelines in . . .
    Biomarkers for Systemic Therapy As the role of targeted therapy for treatment of advanced or mCRC has become increasingly prominent, the NCCN panel has expanded its recommendations regarding biomarker testing Currently, determination of tumor gene status for KRAS NRAS and BRAF mutations, as well as HER2 amplifications and microsatellite instability (MSI) mismatch repair (MMR) status (if not
  • Management of BRAF-mutant metastatic colorectal cancer: a review of . . .
    Herein, we review the clinical and translational literature on the role of the BRAF V600E mutation in the pathogenesis of mCRC, its mechanisms as a prognostic marker, and its potential utility as a predictive marker of treatment response We then summarize the current evidence-based recommendations for management of BRAF V600E-mutated mCRC, with a focus on recent clinical research advances in
  • FDA Approves Encorafenib Combination for BRAF V600E . . . - Pharmacy Times
    Encorafenib is an oral small molecule kinase inhibitor that targets BRAF V600E and is used for various cancer types It received initial approval in 2024 in combination with cetuximab and mFOLFOX6 (leucovorin calcium [folinic acid], fluorouracil, and oxaliplatin) for the treatment of patients with mCRC with a BRAF V600E mutation
  • Encorafenib, cetuximab and chemotherapy in BRAF-mutant . . . - Nature
    Encorafenib + cetuximab (EC) is approved for previously treated BRAF V600E-mutant metastatic colorectal cancer (mCRC) based on the BEACON phase 3 study Historically, first-line treatment of BRAF
  • BREAKWATER: Primary analysis of first-line (1L) encorafenib + cetuximab . . .
    BREAKWATER: Primary analysis of first-line (1L) encorafenib + cetuximab (EC) + FOLFIRI in BRAF V600E-mutant metastatic colorectal cancer (mCRC) If you have the appropriate software installed, you can download article citation data to the citation manager of your choice Simply select your manager software from the list below and click Download





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