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  • Aggrecan - Wikipedia
    Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene [5] This gene is a member of the lectican ( chondroitin sulfate proteoglycan ) family
  • ACAN mutations as a cause of familial short stature - PMC
    ACAN haploinsufficiency is a newly discovered cause of short stature with accelerated bone age Further studies are needed to determine the incidence of ACAN mutations in patients with idiopathic short stature and to clarify the effectiveness and safety of GH and GnRH analog treatment for patients with ACAN mutations
  • ACAN Gene - GeneCards | PGCA Protein | PGCA Antibody
    ACAN (Aggrecan) is a Protein Coding gene Diseases associated with ACAN include Spondyloepimetaphyseal Dysplasia, Aggrecan Type and Spondyloepiphyseal Dysplasia, Kimberley Type Among its related pathways are Integrin Pathway and Keratan sulfate biosynthesis
  • ACAN gene - MedlinePlus
    The ACAN gene variant associated with this condition changes a single protein building block (amino acid) in the CLD of the aggrecan protein Specifically, the amino acid valine is replaced by the amino acid methionine at protein position 2303 (written as Val2303Met or V2303M)
  • Acan Coral: Care, Placement, Growth, Lighting (Beginners . . .
    Acan corals are one of the easiest LPS corals to take care of, making them suitable corals for beginners Available in different varieties and amazing colors, the Acan corals certainly make every saltwater aquarium more beautiful
  • ACAN Gene: Function, Mutations, and Related Conditions
    Conditions Associated with ACAN Gene Mutations Mutations within the ACAN gene disrupt the production of the aggrecan protein, leading to skeletal disorders These conditions impact cartilage and bone development, causing varied but related symptoms The type and severity of the disorder depend on how the specific mutation affects the aggrecan
  • Genotype and phenotype in patients with ACAN gene variants . . .
    Stattin et al first reported 15 ACAN mutation‐related familial OCD patients in a large family with early‐onset OA and disproportionate short stature (Stattin et al , 2008, 2010) To date, 8 ACAN variants (5 missense, 2 nonsense, and 1 frameshift) have been associated with OCD in 24 individuals (Table 1)
  • ACAN! Architects Climate Action Network UK
    ACAN is a network of individuals within architecture and construction, taking action in response to the climate and ecological crises ARCHITECTS CAN! ACAN exists to transform the way our built environment is made, operated and renewed in response to the climate and ecological crises
  • Entry - *155760 - AGGRECAN; ACAN - OMIM - (OMIM. ORG)
    Using primers based on rat and chicken Acan for PCR of a human fetal cartilage cDNA library, Baldwin et al (1989) obtained a partial ACAN clone The deduced protein contains an EGF -like sequence followed by a C-terminal lectin-like domain ACAN also contains a number of ser-gly pairs, which are potential sites for O-linked sugar attachment
  • Aggrecan and versican: two brothers close or apart - PubMed
    Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix They share the same structural domains at both N- and C-termini The N-terminal G1 domain binds hyaluronan (HA), forms an HA-rich matrix, and regulates HA-mediated signaling The C-terminal G …





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