英文字典中文字典


英文字典中文字典51ZiDian.com



中文字典辞典   英文字典 a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z       







请输入英文单字，中文词皆可：


请选择你想看的字典辞典：
单词字典翻译
ancfull查看　ancfull　在百度字典中的解释百度英翻中〔查看〕
ancfull查看　ancfull　在Google字典中的解释Google英翻中〔查看〕
ancfull查看　ancfull　在Yahoo字典中的解释Yahoo英翻中〔查看〕

安装中文字典英文字典查询工具!


中文字典英文字典工具:
选择颜色:
输入中英文单字

































































英文字典中文字典相关资料:


  • Targeting epigenetic regulators to overcome drug resistance in the . . .
    The limited arsenal of effective antifungal agents underscores the urgent need for novel strategies Here, we systematically evaluate the role of histone H3 post-translational modifications in C auris drug resistance, focusing on acetylation mediated by Gcn5 and Rtt109, and methylation mediated by Set1, Set2, and Dot1
  • Targeting epigenetic regulators to overcome drug resistance in the . . .
    Our research demonstrates that the disruption of genes encoding these histone H3 PTM writers leads to varied susceptibilities to a range of antifungal agents Specifically, the histone H3
  • Advances in Antifungal Drug Development: An Up-To-Date Mini Review
    During their screening campaign, Novartis have identified a novel antifungal agent and a novel fungal target pathway, which is hemebiosynthesis The identification of molecular targets opened the window for medicinal chemists to design inhibitors following a target-based drug design approach
  • Antifungal drugs: New insights in research development
    In this review, we discuss the development of antifungal drugs focusing on the approach of drug repurposing and the search for novel drugs for classical targets, the most recently described gene targets for drug development, the possibilities of immunotherapy using antibodies, cytokines, therapeutic vaccines and antimicrobial peptides 1
  • Antifungal therapy: Novel drug delivery strategies driven by new . . .
    In this review, we provide an overview of recent advancements in new antifungal drug delivery strategies that leverage novel targets, including those located in the physio-pathological barrier at the site of infection, the infection microenvironment, fungal-host interactions, and the fungal pathogen itself
  • Epigenetics-targeted drugs: current paradigms and future challenges
    This review delineates the roles of epigenetics in physiological and pathological contexts and underscores pioneering studies on the discovery and clinical implementation of
  • The Future of Antifungal Drug Therapy: Novel Compounds and Targets
    In the following minireview, we provide a comprehensive summary of compounds aimed at one or more novel molecular targets We also briefly describe potential pathways relevant for fungal pathogenesis that can be considered for drug development in the near future An estimated 1 7 billion individuals suffer from fungal infections worldwide (1, 2)
  • An insight into new strategies and targets to combat antifungal . . .
    Present innovation uncovers novel antifungal compounds of Formula 1, containing Fluconazole pharmacophore moieties combined with different moieties including aryl enones and chalcones and chemically OK salts thereof, strategies for setting up these mixtures and drug arrangements containing these clever mixtures for counteraction and treatment
  • Genomic Approaches to Antifungal Drug Target Identification and . . .
    In this review, we explore a variety of current chemical-genomic approaches to define the targets of antifungal compounds using the model yeast Saccharomyces cerevisiae as well as other clinically important fungal pathogens, such as Candida albicans and Cryptococcus neoformans
  • New treatment options for critically important WHO fungal priority . . .
    This review provides succinct insights into novel antifungals in development, aiming to contribute valuable information and perspectives with a focus on recent clinical findings and new treatment approaches for critical members of the WHO fungal pathogen priority list
  • Epigenetics-targeted drugs: current paradigms and future . . . - PubMed
    Additionally, numerous epigenetics-targeted drugs are undergoing clinical trials, offering promising prospects for clinical benefits This review delineates the roles of epigenetics in physiological and pathological contexts and underscores pioneering studies on the discovery and clinical implementation of epigenetics-targeted drugs
  • New Ground in Antifungal Discovery and Therapy for Invasive Fungal . . .
    With the increasing incidence of resistance pathogens, such as Candida auris and Aspergillus fumigatus, we assess emerging antifungal agents, including Ibrexafungerp, T-2307, and N′-Phenylhydrazides, which target diverse fungal cell mechanisms
  • Novel antifungals and treatment approaches to tackle resistance and . . .
    Here, we provide a comprehensive review of novel antifungal agents, with both improved known mechanisms of actions and new antifungal classes, currently in clinical development for treating invasive yeast, mold (filamentous fungi), Pneumocystis jirovecii infections, and dimorphic fungi (endemic mycoses)
  • Target- and prodrug-based design for fungal diseases and cancer . . .
    In this review, we summarize new antifungal targets and target-based inhibitor design, with a focus on their antifungal activity, selectivity, and mechanism We also illustrate the prodrug design strategy used to improve the physicochemical and pharmacokinetic profiles of antifungal agents
  • Novel antifungal agents in clinical trials - PMC - PubMed Central (PMC)
    Herein, we review the antifungal pipeline for agents in clinical phases of development We give particular attention to investigational drugs with novel mechanisms targeting cellular and biochemical pathways Mechanism of action Glycosylphosphatidylinositol (GPI)-anchored mannoproteins are one of the major cell wall components of fungi





中文字典-英文字典  2005-2009