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  • I Expect Therefore I Avoid? The Effects of Negative Expectancy Learning . . .
    Source: The journal of pain Authors: Putu Gita Nadinda, Antoinette I M van Laarhoven, Johan W S Vlaeyen, Madelon L Peters, Andrea W M Evers, Publication Date: Wed, 23 Jul 2025 06:00:00 -0400 J Pain 2025 Jul 21:105506 doi: 10 1016 j jpain 2025 105506 Online ahead of print ABSTRACT Expectancies and avoidance behavior are key factors influencing pain perception…
  • Cannabinoid CB2 receptor controls chronic itch by regulating spinal . . .
    Chronic itch is a devastating clinical condition, and its central mechanisms remain poorly understood We reported that spinal cannabinoid receptor type 2 (CB 2 R) activation exerts antipruritic effects and that itch escalates in mice lacking Cnr2 in mouse models of dermatitis and psoriasis In the spinal cord, CB 2 R is mainly expressed in microglia, and microglial ablation or inhibition
  • Hidradenitis Suppurativa. - Pain Research Forum
    Source: Annu Rev Med 2025 Jan; 76(1) doi: 10 1146 annurev-med-051223-031234Authors: McCarthy S Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the formation of nodules, abscesses, and fistulae at intertriginous sites Pain, pruritus, malodor, and suppuration have a significant impact on quality of life for HS patients Prevalence figures vary greatly in
  • Nerve injury disrupts temporal processing in the spinal cord dorsal . . .
    How mechanical allodynia following nerve injury is encoded in patterns of neural activity in the spinal cord dorsal horn (DH) remains incompletely understood We address this in mice using the spared nerve injury model of neuropathic pain and in vivo electrophysiological recordings Surprisingly, despite dramatic behavioral over-reactivity to mechanical stimuli following nerve injury, an





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