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  • Different %CV between Phoenix and Classic Winnolin PK model
    Different %CV between Phoenix and Classic Winnolin PK model - posted in Phoenix WNL basics: Dear Phoenix Users, I have used two different approaches to characterize the pk data obtained after sc administration of a drug in mice: 1 2 cmt phoenix model 2 2 cmt classic winnolin model Both the models provide reasonable fit to the data However, the parameter estimates from phoenix model have
  • Model Building Syntax with Phoenix - Phoenix WNL basics
    Model Building Syntax with Phoenix - posted in Phoenix WNL basics: Dear all, I want to model my individual observed data (it is not a population analysis) which requires me to write my own model in order to test some hypothesis I have some questions regarding the structure and syntax of a user model: 1 Does Phoenix require at some points to write analytical solutions? Or only differential
  • lagtime model diff equations - Page 2 - Modelling and Simulation
    Page 2 of 2 - lagtime model diff equations - posted in Modelling and Simulation: Emily: Many thanks; this is brilliant: there are 3 different optional models As I understand it each model is independent of the other 2 models The Savic model (from Sweden) does not pull information from the others It is independent Yes? It was originally for NONMEM I have that program here, but I lost
  • Preparing datasets for NLME - Modelling and Simulation
    Preparing datasets for NLME - posted in Modelling and Simulation: Hello, Several people have asked how to prepare datasets for NLME I thought it would be a good idea to open a thread for this topic, because it depends on the format of the original dataset(s) and the model you want to fit So, if anyone wants to share sample datasets or let us know what format your original data is in, we can
  • deconvolution - Page 2 - IVIVC - Certara Forums
    Page 2 of 2 - deconvolution - posted in IVIVC: Simon: I have to try and follow what you are doing I assume you have 3 different ka corresponding to each of the 3 dose I must say I do not follow the reference in your prior example to dose points 0 1, 2 I did not follow that concept I have to try and do this using the dose tables you decribe, but also using the graphics to add the different
  • PML School Schedules 2016 2017 - Certara Forums
    Simultaneously model plasma data of a drug and a metabolite following 5-minute infusion Metabolite clearance follows Michaelis-Menten kinetics October 20, 2017 | 10am EST
  • logistic regression modeling - Modelling and Simulation
    Page 1 of 2 - logistic regression modeling - posted in Modelling and Simulation: Hi, Im trying to build a multiple-category proportional-odds logistic model I understand that I can do this with the multi statement, but Im finding practical examples pretty thin on the ground in the documentation Ive been through the examples (NLME 1 2 Users Guide, p40; Phoenix 1 3 Modeling Language Ref Guide
  • predictive check when nonparametric engine is used
    predictive check when nonparametric engine is used - posted in Modelling and Simulation: Hi Emily, A few months ago you posted a reply to an enhancement suggestion regarding Monte Carlo simulations and pred check (see below) I have a question regarding point a) First Monte Carlo step in your reply below How does Phoenix NLME perform this step when the non-parametric engine is selected, since


















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