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  • SAMSCA® (tolvaptan) Dose Administration
    SAMSCA is indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia (serum sodium <125 mEq L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction), including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Limitations of Use:
  • Continuation Post-Discharge | SAMSCA® (tolvaptan)
    SAMSCA should be initiated and re-initiated in patients only in a hospital where serum sodium can be monitored closely Too rapid correction of hyponatremia (e g , >12 mEq L 24 hours) can cause osmotic demyelination resulting in dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma and death
  • Clinical Trial Efficacy | Hyponatremia in SIADH - SAMSCA
    INDICATION: SAMSCA is indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia (serum sodium <125 mEq L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction), including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Limitations of Use:
  • SAMSCA® (tolvaptan) Patient Selection
    SAMSCA should be initiated and re-initiated in patients only in a hospital where serum sodium can be monitored closely Too rapid correction of hyponatremia (e g , >12 mEq L 24 hours) can cause osmotic demyelination resulting in dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma and death
  • Relationship of Vasopressin to Dilutional Hyponatremia - SAMSCA
    Learn about the relationship of vasopressin to dilutional hyponatremia See full safety and prescribing information, including boxed warning
  • Pathophysiology of Hyponatremia in Heart Failure| SAMSCA® (tolvaptan)
    INDICATION: SAMSCA is indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia (serum sodium <125 mEq L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction), including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Limitations of Use:
  • Hyponatremia Management | SAMSCA® (tolvaptan)
    Read about SAMSCA and the management of dilutional hyponatremia See full safety and prescribing information, including boxed warning
  • Pathophysiology of SIADH Hyponatremia | SAMSCA® (tolvaptan)
    INDICATION: SAMSCA is indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia (serum sodium <125 mEq L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction), including patients with heart failure and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Limitations of Use:


















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