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  • Valproate | ALZFORUM
    Valproate is an anti-convulsant and mood-stabilizing drug that is FDA- and EMA-approved to treat seizures, manic episodes associated with bipolar disorder, and to prevent migraine headaches
  • Mthfr*C677T APOE4 Trem2*R47H - ALZFORUM
    This triple mutant line carries a humanized Apoe gene (ε4 allele), the R47H mutation knocked into mouse Trem2, and the A262V mutation knocked into mouse Mthfr The latter amino acid substitution models the human C677T polymorphism This line may be useful for studying late-onset sporadic Alzheimer’s disease
  • Are Hormones to Blame for High Tau in Women? - ALZFORUM
    “To our knowledge, this is the first study to show that tau deposition may underlie the pre-established association between late HT intervention and AD dementia,” the authors wrote Even so, female sex hormones are not the whole story (for review, see Cui et al , 2023) Other studies have tied tangles to X-linked genes, as either risk or protective factors (Aug 2020 news; Oct 2022 news
  • Rocking Improves Sleep and Memory in Adults - ALZFORUM
    Rocking isn’t just for babies anymore—it can soothe slumbering adults, too Two papers in the January 24 Current Biology online suggest that a gentle, rhythmic sway throughout the night promotes sleep and memory In the first study, scientists led by Laurence Bayer, University of Geneva, report
  • Therapeutics Search | ALZFORUM
    Target Type alpha-synuclein Amyloid-Related Cholesterol Cholinergic System Inflammation Metals Other Other Neurotransmitters Tau Unknown
  • Ponezumab - ALZFORUM
    Overview Name: Ponezumab Synonyms: PF-04360365 Therapy Type: Immunotherapy (passive) (timeline) Target Type: Amyloid-Related (timeline) Condition (s): Alzheimer's Disease, Cerebral Amyloid Angiopathy U S FDA Status: Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) Company: Pfizer Approved for: None Background Ponezumab (PF-04360365) is a therapeutic antibody
  • Genetics - ALZFORUM
    HEX (HEALTHY EXOMES) The Healthy Exomes database is a repository of genetic variants predicted to be benign with respect to age-associated neurodegenerative brain disease It contains whole-exome sequencing results from nearly 500 individuals over the age of 60 who did not have a neurodegenerative disease diagnosis or disease-associated neuropathology at the time of their death This database





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