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  • Age-Related Macular Degeneration (AMD): Pathophysiology, Drug . . .
    Approaches for the treatment of AMD Novel drug delivery systems and route of administration for AMD 2023 : Advanced nanomedicines for the treatment of age-related macular degeneration: Latest pre-clinical treatment options in ocular drug delivery to the retina Explores the advantages of nanoparticle-based therapeutic approaches for AMD 2024
  • Gene therapy for age-related macular degeneration: a . . .
    Age-related macular degeneration (AMD) is a leading cause of central vision loss, progressively impairing the retina and affecting millions worldwide By 2040, global cases of AMD are projected to reach 300 million, posing a significant public health challenge While early AMD may only cause mild visual impairment, advanced stages, particularly neovascular (wet) and non-neovascular (dry) AMD
  • Targeting senescent cells for the treatment of age-associated . . .
    Furthermore, anti-inflammatory therapy targeting the IL-1β pathway with canakinumab administered at 150 mg every 3 months significantly reduced recurrent cardiovascular events compared to placebo in the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) study, independent of lipid-lowering effects This suggests that suppressing
  • Advances in molecular pathology and therapy of non-small cell . . .
    Then, we elaborate on drug resistance mechanisms, mainly involving targeted therapies and immunotherapies, revealed by our proposed theoretical models to clarify interactions between cancer cells
  • Modern approaches for evaluating treatment effect . . .
    In this paper, we review recent advances in statistical methods for the evaluation of the heterogeneity of treatment effects (HTE), including subgroup identification and estimation of individualized treatment regimens, from randomized clinical trials and observational studies We identify several ty …
  • Tissue‐Specific Analysis of Pharmacological Pathways
    We tested whether drugs with similar chemical structure or medical indication will target similar pathways in the same tissue We found that the similarity of target pathways increases exponentially with chemical similarity of drugs and remains consistently higher than the similarity of target proteins ( Figure 4 4 a–d )
  • Inferring actual treatment pathways from patient records
    Defrag offers an innovative and effective approach for inferring treatment pathways from complex health data Defrag significantly outperforms several existing pathway-inference methods, but computationally-derived treatment pathways are still difficult to compare against clinical guidelines





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