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  • Variant of Uncertain Significance (VUS)
    When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
  • What to do if your genetic test finds a variant of uncertain . . .
    Genetic testing can uncover mutations that increase a person’s risk for cancer or offer reassurance when no mutations are found But tests may also find a “variant of uncertain significance” – a mutation that, due to lack of data, remains a mystery and poses more questions than answers
  • Understanding genetic variants of uncertain significance - PMC
    WHY IS THIS IMPORTANT? Paediatricians order many first-line genetic tests, including chromosomal microarrays and gene panels These tests may identify variants of uncertain significance (VUSs) A basic understanding of this type of result is important for test interpretation and clinical management VUSs can be easily misinterpreted by healthcare providers and families WHAT ARE VUSs? A five
  • What Is a VUS? Variants of Unknown Significance in Genetic Testing and . . .
    What should you do if you have a variant of unknown significance in genetic testing results? Hear from experts in the neuromuscular field
  • Invitae follow-up testing: VUS family variant testing
    Invitae follow-ups help patients and families get the answers they need Explore options for genetic testing re-requisition, VUS, and family variants
  • Genetic Test Result: VUS - Variant of Uncertain Significance
    Could a VUS result get changed? A VUS result could get changed to either benign or pathogenic with new information For some variants, a different test can measure if the gene is working or not Or a future study may describe how the variant affects the gene We may learn that the variant is found in healthy people, or in people with a genetic condition Sometimes it takes months or years to
  • Variants of Uncertain Significance: Should We Revisit How They Are . . .
    The ACMG categories for classifying variants are shown, ranging from benign to pathogenic, with greater degrees of pathogenicity shown as increasingly more darkly shaded boxes The middle gray box is the variant of uncertain significance (VUS) Even though there is one class of VUS (represented here as one shade of gray), VUS classification could be subdivided into low, medium or high
  • What’s a “Variant of Uncertain Significance?” A VUS?
    Seven words someone taking a genetic test doesn’t want to hear: “You have a variant of uncertain significance ” A VUS Instead of a yes or no answer – a gene has a mutation or it doesn’t – a VUS is a “not the usual, but we don’t know if it’s harmful ” A maybe (NHGRI) But like a typo to just one letter on a page, single DNA base substitutions in a gene’s sequence might
  • Variant of uncertain significance (VUS) — Knowledge Hub
    A variant of uncertain significance is a genomic variant about which there is insufficient data to conclude that it is either benign or pathogenic





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