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deoxyribonucleotide    
脱氧核糖核甙酸

脱氧核糖核□酸


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  • Deoxyribonucleotide - an overview | ScienceDirect Topics
    Infection with these phage results in the synthesis of new enzymes, which affects the normal deoxyribonucleotide content, resulting in the synthesis of the unusual deoxyribonucleotide In phage T4-infected E coli , evidence has been presented that deoxyribonucleotides are synthesized by a multienzyme complex that both facilitates this process
  • Deoxyribonucleotide - an overview | ScienceDirect Topics
    Deoxyribonucleotide In subject area: Neuroscience A deoxyribonucleotide is a molecule that is defined as a building block of DNA, synthesized through the reduction of ribonucleosides diphosphates in the biosynthetic pathway to deoxynucleotides
  • Deoxyribonucleotide - an overview | ScienceDirect Topics
    1 08 6 Deoxyribonucleotide Biosynthesis Deoxyribonucleotides are all derived de novo from one enzyme system, the ribonucleotide reductase The enzyme is a hetero-tetramer with two catalytic and regulatory subunits (R1) and two subunits dedicated to the generation of the important radical (R2)
  • Deoxyribonucleotide - an overview | ScienceDirect Topics
    There are 2 pathways for both deoxyribonucleotide and ribonucleotide synthesis, called the de novo pathway and the salvage pathway (Fig 2A) (Reichard, 1988) Via the de novo ribonucleotide pathway, ribonucleotides are synthesized from small molecules (e g , amino acids, ribose-5′-phosphate, and CO 2 ) to ribonucleoside monophosphates and
  • Deoxyribonucleoside - an overview | ScienceDirect Topics
    The reversibility of deoxyribonucleoside phosphorolysis suggests that bases might be elevated to the deoxyribonucleotide level by successive actions of B+dR1P ↔ Phosphorylase BdR → kinase BdRP The first step, deoxyribonucleoside synthesis, has been demonstrated in vitro with purified preparations of purine ribonucleoside Phosphorylase and
  • Polydeoxyribonucleotide: A promising skin anti-aging agent
    ROS, an unavoidable consequence of aerobic metabolism in the mitochondrial electron transport chain, are a major cause of skin aging 23 Although the presence of small amounts of ROS exerts beneficial effects in maintaining the health of cells, ROS induce and accelerate major skin aging cascades that result in decreased collagen production, increased expression of pro-inflammatory cytokines
  • Oxidation in the nucleotide pool, the DNA damage response and cellular . . .
    Oxidation in the deoxyribonucleotide pool affects the integrity of genomic DNA not only by increasing the probability of transversion mutations but also by introducing DNA strand breaks that trigger persistent DDR signaling through several likely pathways (Fig 1) Sanitization of the nucleotide pool by the NUDT family of proteins, notably MTH1
  • Terminal Deoxynucleotidyl Transferase Indiscriminately Incorporates . . .
    The value of the TdT selectivity factor S for each ribo deoxyribonucleotide pair (rATP dATP, rUTP dTTP, rGTP dGTP, and rCTP dCTP) was experimentally determined in a chain elongation assay, under conditions where both types of nucleotides are present and where there is a single nucleotide addition to the nucleic acid initiator Because the
  • Deoxyribonucleoside Triphosphate - an overview - ScienceDirect
    Infection with these phage results in the synthesis of new enzymes, which affects the normal deoxyribonucleotide content, resulting in the synthesis of the unusual deoxyribonucleotide In phage T4-infected E coli , evidence has been presented that deoxyribonucleotides are synthesized by a multienzyme complex that both facilitates this process
  • Deoxyribonucleoside - an overview | ScienceDirect Topics
    In most organisms, the major strategy for salvage of purine ribonucleosides and deoxyribonucleosides (Figure 4) is the phosphorolytic cleavage by purine nucleoside phosphorylases, and a subsequent phosphoribosylation by phosphoribosyl transferases to obtain the corresponding ribonucleoside monophosphate





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