Caspase 7 - Wikipedia Function Caspase-7 is a member of the caspase (c ysteine asp artate prote ase) family of proteins, and has been shown to be an executioner protein of apoptosis Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis
Caspase-7: A protease involved in apoptosis and inflammation The described roles of caspase-7 in apoptosis and inflammation suggest that interfering with caspase-7 activation may prove beneficial in conditions where excessive cell death and or inflammation contribute to disease
Caspase-7 activates ASM to repair gasdermin and perforin pores Mechanistically, caspase-7 counteracts gasdermin D pores and preserves cell integrity by cleaving and activating acid sphingomyelinase (ASM), which thereby generates copious amounts of ceramide
CASP7 - Caspase-7 - Homo sapiens (Human) | UniProtKB Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity)