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unsmooth    
不光滑

不光滑

unsmooth
adj 1: having or caused by an irregular surface; "trees with
rough bark"; "rough ground"; "rough skin"; "rough
blankets"; "his unsmooth face" [synonym: {rough}, {unsmooth}]
[ant: {smooth}]

Unsmooth \Unsmooth\
See {smooth}.


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  • Alternate-Day Dosing With Statins - American College of . . .
    4 Steady-state statin drug levels may be achieved in a few days, but steady-state LDL-C reductions take several weeks to achieve, and after discontinuation, it takes several weeks before the cholesterol level returns to baseline 5 The cholesterol-lowering action of alternate-day statins is as effective as daily dosing in many individuals 6
  • Statin side effects: Weigh the benefits and risks - Mayo Clinic
    Another option is to take the medicine every other day, especially if you take a statin that stays in the blood for several days Talk to your healthcare professional to find out if this is right for you
  • Efficacy of alternate day versus daily dosing of rosuvastatin
    Compared with other statins, rosuvastatin has a relatively long half-life, which may allow for the administration of this medication on an alternate day basis To compare the efficacy of administering rosuvastatin on a daily basis versus on an
  • Every-Other-Day Rosuvastatin Dosing in Patients with Statin . . .
    Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population
  • Once-a-Week Rosuvastatin (2. 5 to 20 mg) in Patients With a . . .
    Previous data indicate that using alternative rosuvastatin dosing (every other day, three times a week, and twice a week) in patients with previous statin adverse events can improve patient tolerability and significantly lower total cholesterol and low-density lipoprotein cholesterol (LDL-C) 1–3 The present study demonstrates the efficacy of
  • Non daily dosing of statins - GPnotebook
    The Alternate Day Versus Daily Dosing of Atorvastatin Study (ADDAS) Am Heart J 2002;144:674-7 Backes JM et al Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance Ann Pharmacother 2008;42:341-6 Reinhart KM
  • Alternate-day Dosing with Statins - ScienceDirect
    Thus, the prolonged duration of the cholesterol effect of the statins suggests that statins may be given intermittently, such as every other day, with similar lipid-lowering effects as when administered daily This is a review of published data evaluating the lipid-lowering effects of daily versus intermittent dosing of statins
  • Low Dose Statin Every Other Day - Consensus Academic Search . . .
    Conclusion Low-dose statin therapy administered every other day appears to be an effective and tolerable option for patients who experience statin intolerance Studies have shown significant reductions in LDL-C levels with alternate-day dosing of simvastatin, atorvastatin, and rosuvastatin, with comparable efficacy to daily dosing in many cases





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